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Слабые или умеренно выраженные нарушения функции почек; одновременное применение с сильными ингибиторами изофермента CYP2D6 и умеренными ингибиторами azithromycin chlamydia while pregnant у пациентов с генотипически низкой активностью изофермента CYP2D6 и пациентов с высокой активностью изофермента CYP2D6 (в комбинации с умеренными ингибиторами изофермента CYP3A4); одновременное применение с ЛС, которые влияют на агрегацию тромбоцитов, и с антикоагулянтами из-за риска развития кровотечений.